A virtual national laboratory for reengineering clinical translational science.

One dental hygienist's role in clinical research.

Clinical research is growing quickly in medicine and dentistry today. Moving research findings from the bench top of a scientific laboratory to the private practitioner's clinical setting is what translational research is all about. The National Institutes of Health (NIH) Roadmap 2002 for biomedical research has highlighted translational research within medicine, and that includes oral health, ...

Editorial: New Generation of Psychotherapies Inspired by Cognitive Neuroscience Development: Emergence of Neurocognitive Therapies

Reengineering translational science: the time is right.

Despite dramatic advances in the molecular pathogenesis of disease, translation of basic biomedical research into safe and effective clinical applications remains a slow, expensive, and failure-prone endeavor. To pursue opportunities for disruptive translational innovation, the U.S. National Institutes of Health (NIH) intends to establish a new entity, the National Center for Advancing Translat...

Protective Role of Hypothermia Against Heat Stress in Differentiated and Undifferentiated Human Neural Precursor Cells: A Differential Approach for the Treatment of Traumatic Brain Injury

Introduction: The present study aimed to explore protective mechanisms of hypothermia against mild cold and heat stress on highly proliferative homogeneous human Neural Precursor Cells (NPCs) derived from Subventricular Zone (SVZ) of human fetal brain.  Methods: CD133+ve enriched undifferentiated and differentiated human NPCs were exposed to heat stress at 42°C. Then, Western-blot qua...

Evaluation guidelines for the Clinical and Translational Science Awards (CTSAs).

The National Center for Advancing Translational Sciences (NCATS), a part of the National Institutes of Health, currently funds the Clinical and Translational Science Awards (CTSAs), a national consortium of 61 medical research institutions in 30 states and the District of Columbia. The program seeks to transform the way biomedical research is conducted, speed the translation of laboratory disco...